Andrew Spence received his BFA from Tyler School of Art of Temple University in 1969 and his MFA from the University of California at Santa Barbara in 1971. His first one-person exhibition was at the Nicholas Wilder Gallery in Los Angeles in 1974. His work was included in the 1975 Whitney Biennial exhibition at the Whitney Museum of American Art in New York City.
In 1977, Spence moved to New York City where he lives presently. He has been included in several museum exhibitions nationally. In 1987 his work was in the 40th Biennial Exhibition of Contemporary Art at the Corcoran Gallery in Washington D.C. and later included in the 1989 Whitney Biennial Exhibition. Spence has exhibited his paintings exclusively at Barbara Toll Fine Arts, Max Protetch Gallery and Edward Thorp Gallery. His paintings are known for their eccentric distillation between abstraction and reference.
Spence received a National Endowment for the Arts award in painting in 1987 and a Guggenheim Fellowship in painting in 1994. His artwork is in major museum collections including the Whitney Museum of American Art, The Metropolitan Museum of Art, The Museum Of Modern Art, the Philadelphia Museum of Art, the San Diego Museum of Contemporary Art, the Walker Art Center and the Albright-Knox Gallery.